rs1229984 protective_against alcohol dependence
Evidence from:
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Evidence (4 sources)
Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.
(2021)
PMID:32652861
primary
other variants in this gene, e.g., rs1229984, also have protective effects
confidence: 0.94
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
(2013)
PMID:23607416
primary
when this coding variant was directly genotyped in the COGA sample, a genome-wide significant association with AD was revealed, with a strong protective effect
confidence: 0.95
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
(2013)
PMID:23743675
primary
The minor allele of rs1229984 ... was previously shown to be protective against alcohol dependence in Asian samples
confidence: 0.95
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
(2017)
PMID:28485404
cited
individuals who carry at least one copy of rs1229984 ... might be less likely to develop ... dependence to alcohol
confidence: 0.94