CRF targets CRF2R
Evidence from:
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Evidence (4 sources)
CRF ... act differentially at ... CRF2 synaptic receptors
confidence: 0.96
CRF binds to both receptors, but has greater affinity for the CRF1R.
confidence: 0.94
Stress-related neuropeptides and addictive behaviors: beyond the usual suspects.
(2012)
PMID:23040815
cited
effect was blocked by CRF2R but not CRF1R antagonists
confidence: 0.94
Stress-related neuropeptides and addictive behaviors: beyond the usual suspects.
(2012)
PMID:23040815
cited
CRF is largely a CRF1R agonist and displays 18-fold greater affinity for CRF1R than CRF2R
confidence: 0.85