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UKB associated_with alcohol dependence

Subject
UKB
Relation
associated_with
Object
alcohol dependence
p-value
1.8e-08
Evidence from: primary | all sources

Evidence (6 sources)

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. (2022) PMID:33985350 primary
AUDIT-P exhibited strong positive associations with alcohol dependence
confidence: 0.96
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary
genetic correlation with alcohol dependence was nominally greater for AUDIT-P scores (rg = 0.63) than AUDIT-C scores (rg = 0.33)
confidence: 0.90
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. (2019) PMID:30336701 cited
AUDIT-P showed a nominally stronger genetic correlation with alcohol dependence (rg = 0.63, p = 1.8 × 10−8).
confidence: 0.98
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. (2019) PMID:30336701 cited
We hypothesized that AUDIT-P would correlate more strongly with measures of hazardous substance use, including alcohol dependence...
confidence: 0.95
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. (2019) PMID:30336701 cited
AUDIT-P showed a strong genetic correlation with alcohol dependence
confidence: 0.96
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. (2019) PMID:30336701 cited
We also used LDSC to examine genetic correlations between various dichotomized versions of AUDIT and DSM-IV defined alcohol dependence
confidence: 0.92