ALDH2 risk_factor_for alcohol dependence
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Evidence (9 sources)
Another metabolic gene, ALDH2, is associated with alcohol dependence in Asians.
confidence: 0.94
the alcohol metabolism genes ... ALDH2 ... in the predisposition to alcohol use, abuse, and dependence
confidence: 0.95
effect was mostly due to the contribution of the ALDH2 ... loci
confidence: 0.95
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
(2015)
PMID:26110981
cited
two GWS loci in the alcohol metabolizing enzyme gene ALDH2 ... associated with AD case-control status
confidence: 0.88
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
(2015)
PMID:26267224
cited
ALDH2 ... showed AD risk alleles consistent with many prior observations.
confidence: 0.95
genes in the ethanol metabolic pathway (e.g., ALDH2) are candidates for alcohol dependence
confidence: 0.95
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks.
(2012)
PMID:22348705
cited
implicated as risk factors for developing alcohol abuse or dependence
confidence: 0.93
An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back.
(2011)
PMID:34385894
cited
robust association with polymorphisms in genes encoding alcohol metabolizing enzymes: aldehyde dehydrogenase (ALDH)...
confidence: 0.80
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
(2010)
PMID:20098672
cited
acetaldehyde dehydrogenase/alcohol dehydrogenase variants to risk for alcohol dependence in Asians
confidence: 0.94