rs279858 regulates GABRA2
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Evidence (2 sources)
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
(2015)
PMID:26250693
cited
GABRA2 haplotype block containing rs279858 harbors a functional polymorphism with regulatory effects that influence the expression of all four GABAA-subunit genes.
confidence: 0.96
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
(2015)
PMID:26250693
cited
Mixed-effects models examining RT-qPCR GABRA2 RNA levels revealed a significant effect of GABRA2 rs279858 genotype (F=3.7, df=2,15.8, p=0.046). Neural cell cultures ... had lower levels of GABRA2 RNA than T-allele homozygotes.
confidence: 0.95