naltrexone interacts_with OPRM1

Subject: naltrexone
Relation: interacts_with
Object: OPRM1
p-value: —

Evidence from: primary | all sources

Evidence (7 sources)

Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity. (2017) PMID:28134463 cited

Studies examined response to NTX (naltrexone) in relation to OPRM1 variants such as A118G and Asp40.

confidence: 0.89

Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012) PMID:22954510 cited

Interaction with OPMR1 genotype may affect naltrexone response.

confidence: 0.88

Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012) PMID:22954510 cited

preferential binding for mu over kappa receptors ... three to ten times greater; affinity for mu may be as much as 63 times greater

confidence: 0.94

Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012) PMID:22954510 cited

As naltrexone has activity at multiple opioid receptor classes...

confidence: 0.94

The genetics of the opioid system and specific drug addictions. (2012) PMID:22547174 cited

opioid receptor blockade by NTX

confidence: 0.90

Pharmacological treatment of cannabis dependence. (2011) PMID:21524266 cited

Naltrexone is described as a mu‑opioid receptor (mOR) antagonist, and mOR is encoded by OPRM1.

confidence: 0.90

Consilient research approaches in studying gene x environment interactions in alcohol research. (2010) PMID:20148780 cited

naltrexone, an opiate antagonist that has actions at mu opiate receptors

confidence: 0.96