CHRNA5 associated_with heavy smoking
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Evidence (5 sources)
the CHRNA5-A3-B4 gene cluster ... has been consistently shown to contain multiple loci strongly associated with heaviness of smoking
confidence: 0.92
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes.
(2012)
PMID:22290489
cited
genetic variants in the α5/α3/β4 nAChR gene cluster as associated with ... heaviness of smoking
confidence: 0.95
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
different levels of expression for CHRNA5 messenger RNA (mRNA) ... are associated with heavy smoking
confidence: 0.90
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.
(2009)
PMID:19132693
cited
replicated the association of CHRNA5 ... with smoking and nicotine dependence.
confidence: 0.95
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.
(2009)
PMID:19132693
cited
CHRNA5 ... locus is associated with heavy smoking ...
confidence: 0.95