Fgf21 protective_against hepatic steatosis

Subject: Fgf21
Relation: protective_against
Object: hepatic steatosis
p-value: —

Evidence from: primary | all sources

Evidence (4 sources)

CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. (2019) PMID:29568101 primary

FGF21 knockdown caused both hepatic steatosis ...

confidence: 0.94

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. (2016) PMID:26838599 cited

FGF21 has been shown to reduce steatosis and lipotoxic lipids

confidence: 0.95

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. (2016) PMID:26838599 cited

FGF21 prevents steatosis in different mouse models.

confidence: 0.90

Stressed Liver and Muscle Call on Adipocytes with FGF21. (2013) PMID:24385972 cited

FGF21-elicited adipocyte signals ... alleviate the extent of hepatic steatosis

confidence: 0.94