PPARα−/− mice risk_factor_for hepatic steatosis
Evidence from:
primary |
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Evidence (3 sources)
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
(2019)
PMID:29568101
primary
Fasted pparα−/− mice exhibited more severe steatosis than fasted wild type mice
confidence: 0.90
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
(2016)
PMID:26838599
cited
Mice lacking PPARα develop steatosis during fasting, suggesting the importance of PPARα activity.
confidence: 0.94
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
(2016)
PMID:26838599
cited
Compared with WT, Pparα−/− ... showed greater steatosis
confidence: 0.95