APP risk_factor_for fAD
Evidence from:
primary |
all sources
Evidence (5 sources)
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
(2018)
PMID:29632371
cited
human APP with mutations that cause familial AD
confidence: 0.94
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
Mutations in amyloid precursor protein (APP)... cause familial AD (FAD)
confidence: 0.95
families have been identified in which a duplication of the APP gene leads to FAD
confidence: 0.94
Mutations in 3 genes including APP have been identified as causing familial Alzheimer’s disease (FAD).
confidence: 0.97
FAD mutations in APP
confidence: 0.95