body mass index risk_factor_for major depressive disorder

Subject: body mass index
Relation: risk_factor_for
Object: major depressive disorder
p-value: 1.2e-07

Evidence from: primary | all sources

Evidence (2 sources)

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (2018) PMID:29700475 cited

MR analyses provided evidence for a 1.12-fold increase in major depression per standard deviation of BMI (PGSMR=1.2×10−7)

confidence: 0.95

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (2018) PMID:29700475 cited

significant positive genetic correlations with measures of body mass ... MR analysis results are consistent with BMI being causal ... risk factor for major depression

confidence: 0.92