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Fgf21 interacts_with FGFR1

Subject
Fgf21
Relation
interacts_with
Object
FGFR1
p-value
—
Evidence from: primary | all sources

Evidence (4 sources)

Stressed Liver and Muscle Call on Adipocytes with FGF21. (2013) PMID:24385972 cited
adipose tissue and adipocyte FGFR1‑KLB is the primary tissue and molecular target of inter‑organ messenger FGF21
confidence: 0.95
Stressed Liver and Muscle Call on Adipocytes with FGF21. (2013) PMID:24385972 cited
FGF21-FGFR1-KLB mediated uncoupling
confidence: 0.93
Stressed Liver and Muscle Call on Adipocytes with FGF21. (2013) PMID:24385972 cited
KLB is present as a binary complex with FGF receptor tyrosine kinases (FGFR).
confidence: 0.94
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. (2012) PMID:22792234 cited
FGF21 binds fibroblast growth factor receptor (FGFR) tyrosine kinases ... activates MAPK preferentially via FGFR1c/β-klotho
confidence: 0.96