PSEN1 risk_factor_for Alzheimer's disease
Evidence from:
primary |
all sources
Evidence (3 sources)
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
Mutations in PSEN1 could bring about alterations ... which might participate in the development of neurodegeneration in AD.
confidence: 0.95
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
causal roles of PSEN1 mutants in AD via an Aβ-independent manner
confidence: 0.94
Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging.
(2011)
PMID:22216330
cited
mutations in ... presenilins (PSEN1 or PSEN2) ... lead to increased levels of aggregated Aβ
confidence: 0.85