GAD2 regulates GABA
Evidence from:
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Evidence (3 sources)
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
(2012)
PMID:22253714
cited
These genes encode enzymes that synthesize GABA from glutamate.
confidence: 0.92
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
are responsible for catalyzing glutamate to produce GABA in the brain
confidence: 0.96
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
(2009)
PMID:19111404
cited
GAD is the rate-limiting enzyme for synthesis of GABA in the brain
confidence: 0.96