OPHN1 risk_factor_for mental retardation

Subject: OPHN1
Relation: risk_factor_for
Object: mental retardation
p-value: 0.001

Evidence from: primary | all sources

Evidence (3 sources)

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (2009) PMID:19377476 cited

their excess variation may be due to mental retardation–causing missense variants.

confidence: 0.90

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (2009) PMID:19377476 cited

It also highlighted ... four known genes involved in XLMR ... OPHN1 (P = 0.001)

confidence: 0.96

Genetic and environmental factors in complex neurodevelopmental disorders. (2007) PMID:19412416 cited

OPHN1 ... identified as susceptibility genes for MR

confidence: 0.94