CYP2A6 interacts_with nicotine

CYP2A6 accounts for up to 80% of nicotine clearance; CYP2A6 is involved in nicotine oxidation to nicotine iminium ion.

the nicotine metabolizing gene CYP2A6

CYP2A6, is the main metabolic enzyme for nicotine accounting for up to 80% of nicotine clearance.

genes involved in metabolism, such as CYP2A6 (for nicotine) ... are highly likely to have drug-specific effects.

The CYP2A6 enzyme converts nicotine to cotinine and accounts for 70% of initial nicotine metabolism.