CACNA1C risk_factor_for schizophrenia
Evidence from:
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Evidence (6 sources)
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
(2022)
PMID:35396580
cited
Multiple genes encode receptors and ion channels, including voltage-gated calcium ... (CACNA1C ...). The diversity of synaptic proteins ... suggests multiple functional interactions of schizophrenia risk.
confidence: 0.95
Figure 4a shows the CACNA1C intronic association for schizophrenia
confidence: 0.95
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
significant for schizophrenia alone, along with CACNB2
confidence: 0.95
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
CACNA1C ... are also GWAS schizophrenia genes
confidence: 0.93
Support for shared susceptibility was strengthened at CACNA1C (rs4765905, P = 7.0 × 10−9)
confidence: 0.90
enhancement of signals at CACNA1C ... when schizophrenia and bipolar disorder were jointly analyzed
confidence: 0.95