Kcnj6 associated_with Down syndrome
Evidence from:
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Evidence (5 sources)
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Kcnj6 expression is increased in mouse models of DS
confidence: 0.95
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Pharmacological strategies to combat the effect of Kcnj6 gene dose could be considered ... in DS.
confidence: 0.93
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
To address the impact of Kcnj6 triplication on cognitive phenotypes in DS...
confidence: 0.94
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Kcnj6 is present in 3 copies in both people with DS and Ts65Dn mice, a region sufficient to create many DS phenotypes.
confidence: 0.85
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Increased Kcnj6 gene dose ... could contribute to changes ... in people with DS
confidence: 0.90