OPRM1 risk_factor_for opioid dependence
Evidence from:
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Evidence (6 sources)
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
(2022)
PMID:36207451
primary
In the gSEM GWAS we found the strongest statistical evidence ... linking variants in intron 1 of the OPRM1 gene to OA.
confidence: 0.90
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
(2022)
PMID:36207451
primary
linking variants in intron 1 of the OPRM1 gene to OA
confidence: 0.96
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
(2022)
PMID:36207451
primary
haplotype analyses of OPRM1 intron 1 variants... relationship between the underlying EA haplotype structure and risk for OA
confidence: 0.90
genetic variation in OPRM1 may affect susceptibility to opioid dependence in an ethnicity-dependent manner
confidence: 0.85
Haplotype block structure of the genomic region of the mu opioid receptor gene.
(2011)
PMID:21160491
cited
vulnerability to develop opioid addiction is partially inherited and may be attributed to genetic variations.
confidence: 0.60
Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis.
(2009)
PMID:23226031
cited
sequence variants within its coding region are the most frequently studied candidates in association with opioid dependence.
confidence: 0.60