OPRM1 A118G regulates OPRM1
Evidence from:
primary |
all sources
Evidence (3 sources)
Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol.
(2020)
PMID:32561311
primary
Our recent functional study ... found that ... this SNP causes a gain of MOR function.
confidence: 0.92
The G allele ... creates a novel CpG-methylation site, preventing the upregulation of OPRM1 in response to chronic opioid use.
confidence: 0.95
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.
(2012)
PMID:22954510
cited
the 118G variant appears to decrease OPRM1 mRNA and protein yield
confidence: 0.85