PPARA protective_against nicotine

Subject: PPARA
Relation: protective_against
Object: nicotine
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. (2011) PMID:20801430 cited

activation of PPAR-α receptors can counteract addiction-related effects of nicotine

confidence: 0.96

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. (2011) PMID:20801430 cited

Activation of PPAR-α ... prevents nicotine‑induced increases in firing rate ... and dopamine levels.

confidence: 0.95