PSEN1 risk_factor_for neurodegeneration
Evidence from:
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Evidence (2 sources)
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
Mutations in PSEN1 could bring about alterations ... which in turn might participate in the development of neurodegeneration in AD.
confidence: 0.94
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
PSEN1 mutants promote neurodegeneration ... without any increase in Aβ
confidence: 0.96