substance use risk_factor_for depression
Evidence from:
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Evidence (4 sources)
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.
(2023)
PMID:37464041
cited
highest for SUD (86%) and anxiety (89%) in concordant direction of shared variants
confidence: 0.90
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.
(2023)
PMID:37464041
cited
relationship is generally bi-directional ... a significantly increased risk of comorbidity between depression and other ... psychiatric disorders.
confidence: 0.92
Sex differences amongst dependent heroin users: histories, clinical characteristics and predictors of other substance dependence.
(2011)
PMID:20833480
cited
Females with more substance dependence diagnoses were also at increased risk for depression, BPD but not PTSD or ASPD.
confidence: 0.95
Risk is higher for substance dependence (4.2–4.5 fold increase) versus abuse.
confidence: 0.93