rs1051730 risk_factor_for heavy smoking
Evidence from:
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Evidence (2 sources)
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.
(2011)
PMID:21168125
cited
CHRNA3-rs1051730[A] is more common in heavy‑smokers (≥10 cigarettes/day) than non‑smokers.
confidence: 0.93
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
(2009)
PMID:19429911
cited
rs1051730 genotype was associated with smoking quantity during the first trimester ... OR = 1.30 (95% CI 1.13–1.50); P = 0.0003
confidence: 0.96