calcineurin associated_with Alzheimer's disease
Evidence from:
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all sources
Evidence (4 sources)
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
(2010)
PMID:20590401
cited
Understanding the functions of the individual PPP3CA isoforms ... might each provide unique insights into specific AD pathogenetic features.
confidence: 0.90
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
(2010)
PMID:20590401
cited
support roles for PPP3CA ... in AD
confidence: 0.95
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
(2010)
PMID:20590401
cited
selective roles for PPP3CA ... in the pathogenesis of ... AD
confidence: 0.92
Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
(2010)
PMID:20590401
cited
Calcineurin upregulation has been postulated in AD brain due to its involvement in calcium homeostasis...
confidence: 0.92