Val158Met regulates dopamine

Subject: Val158Met
Relation: regulates
Object: dopamine
p-value: —

Evidence from: primary | all sources

Evidence (1 sources)

Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. (2011) PMID:21620981 cited

Increased DA catabolism imparted by the Val allele is thought to result in reduced synaptic DA availability

confidence: 0.90