ATF4 regulates Fgf21
Evidence from:
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Evidence (3 sources)
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
(2016)
PMID:26838599
cited
Amino acid deprivation induces hepatic FGF21 expression through ATF4.
confidence: 0.85
These include ... ATF4 ... that are involved in metabolic stress responses regulate FGF21 expression.
confidence: 0.94
Multiple transcription factors ... have been implicated in control of FGF21 expression ... such as ... ATF4 in the ER stress response.
confidence: 0.90