APP risk_factor_for Alzheimer’s disease
Evidence from:
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all sources
Evidence (2 sources)
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
(2020)
PMID:31986256
cited
highly penetrant mutations in APP ... result in monogenic Alzheimer’s disease
confidence: 0.96
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
A role for increased dosage of APP in the pathogenesis of the Alzheimer’s disease in DS is now supported by studies...
confidence: 0.96