Kcnj6 regulates synaptic plasticity
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Evidence (3 sources)
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Pharmacologically inhibiting Kir3.2-containing channels also restored synaptic plasticity.
confidence: 0.93
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
increased expression of Kir3.2 as suppressing hippocampal synaptic plasticity
confidence: 0.95
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Genetically normalizing Kcnj6 gene dose ... restored synaptic plasticity in the DG
confidence: 0.90