ADH5 associated_with alcohol
Evidence from:
primary |
all sources
Evidence (6 sources)
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
(2019)
PMID:30940813
primary
including three alcohol-metabolizing genes ... ADH5 ... associated with alcohol consumption
confidence: 0.96
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.
(2019)
PMID:30336701
cited
identified numerous loci ... that influence alcohol consumption, including ADH1B/ADH1C/ADH5
confidence: 0.95
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
a cluster of variants spanning the alcohol dehydrogenase genes (ADH1B, ADH1C, ADH5, ADH6, ADH7) ... linked to variation in alcohol consumption
confidence: 0.90
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
identify eight independent loci associated with alcohol consumption... ADH5 is one of the four loci
confidence: 0.95
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
first GWAS of alcohol consumption to detect genome-wide significant association with ADH5
confidence: 0.93
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
several alcohol dehydrogenase genes (ADH1B, ADH1C, ADH5) that have all previously been implicated in alcohol consumption.
confidence: 0.96