rs16969968 associated_with African American
Evidence from:
primary |
all sources
Evidence (6 sources)
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
variation explained by the chromosome 15q25 SNPs rs16969968 ... is 1.9% in both EAs and AAs.
confidence: 0.90
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
(2010)
PMID:20584212
cited
In AAs, rs16969968 has a similar individual R2 of 1.3%.
confidence: 0.95
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
at rs16969968 the AA ... odds ratios are not significantly different (heterogeneity p = 0.24)
confidence: 0.90
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
rs16969968 is the most significant of the 76 SNPs in the AAs alone (p = 0.0147, OR = 2.04...).
confidence: 0.94
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
consistent direction of effect of the “A” risk allele in AAs
confidence: 0.92
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
(2008)
PMID:18783506
cited
Only six African Americans carried one copy of the ‘A’ allele, showing a different allele frequency compared to Caucasians.
confidence: 0.90