CYP2A6 regulates nicotine clearance

Subject: CYP2A6
Relation: regulates
Object: nicotine clearance
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. (2015) PMID:26407342 cited

CYP2A6, is the main metabolic enzyme for nicotine accounting for up to 80% of nicotine clearance.

confidence: 0.95

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

These alleles have reduced activity (slower nicotine clearance)

confidence: 0.94