CACNA1C associated_with bipolar disorder
Evidence from:
primary |
all sources
Evidence (5 sources)
Candidate gene-environment interaction research: reflections and recommendations.
(2015)
PMID:25620996
primary
Robust and replicable GWAS signals (e.g., CACNA1C for ... Bipolar Disorder; Ruderfer et al., 2013)
confidence: 0.95
SNPs for both BP and SCZ were genome-wide significant in CACNA1C
confidence: 0.94
joint analysis with bipolar disorder (three genes, CACNA1C, ANK3 and ITIH3-ITIH4, described below)
confidence: 0.80
CACNA1C ... has previously been associated with bipolar disorder
confidence: 0.85
Genome-wide association study of bipolar disorder in European American and African American individuals.
(2009)
PMID:19488044
cited
further support for the previously reported CACNA1C gene ... ion channelopathies may be involved in the pathogenesis of BD
confidence: 0.94