rs1051730 risk_factor_for lung cancer
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Evidence (3 sources)
Genetic variability in the regulation of gene expression in ten regions of the human brain.
(2014)
PMID:25174004
cited
rs1051730 is a risk SNP for the interlinked phenotypes of lung cancer, smoking behavior and nicotine dependence
confidence: 0.98
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.
(2011)
PMID:21168125
cited
The CHRNA3-rs1051730[A] ... increased susceptibility to develop lung cancer ... among smokers.
confidence: 0.94
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
(2009)
PMID:19429911
cited
Two additional studies have demonstrated highly significant associations between rs1051730 and lung cancer (OR ≈ 1.3; P < 10−8).
confidence: 0.96