de novo variant risk_factor_for Tourette syndrome

11.6% ... of cases have a de novo damaging variant ... contributing to TD risk

de novo LGD variants showing a significantly elevated rate ratio in TD probands (RR 2.14, 95% CI 1.28–3.61, p = 0.006)

22.9% (95% CI 4.8%–41.0%) of de novo damaging variants carry TD risk

evidence for the contribution of de novo damaging variants ... mediating TD risk

Exome sequencing of TD trios establishes the increased rate of de novo LGD variants in cases versus controls.

given the prior evidence for the role of de novo mutations in TD and other neurodevelopmental disorders