ALDH2 risk_factor_for Alcohol Use Disorder
Evidence from:
primary |
all sources
Evidence (2 sources)
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
(2020)
PMID:32451486
primary
Variants mapped to ALDH2 ... are significantly associated with AUD (p < 5 × 10⁻⁸).
confidence: 0.95
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
SNPs in the genes encoding the alcohol metabolizing enzymes ... are among the common variants with the largest effects on AUD risk.
confidence: 0.96