OPRM1 A118G associated_with opioid dependence

previously associated rs1799971 (A118G)

those for rs1799971 were weak (beta = −0.058, p = 0.135) and evidence for an association with OA being driven by rs1799971 was weakened (p = 0.52)

altered propensity for opioid addiction

An association was observed between the 118G allele and opioid addiction in Swedish ...

No association with opioid dependence was found ... analyzing SNP 118A>G

raises questions regarding the ability ... to make reliable conclusions regarding an association, ... between A118G OPRM1 genetics and opioid dependence.

grouping the studies ... did not alter the association between genotype frequencies and opioid dependence

Meta‑analysis attempted to elucidate the nature of the relationship between the A118G polymorphism and opioid dependence.

previous case studies have reported possible association of A118G SNP with opioid dependence in other ethnic groups, such as Hispanics, African-Americans, and Indians

no evidence of a relationship between the A118G OPRM1 SNP and opioid dependence