CACNA1C risk_factor_for bipolar disorder
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Evidence (7 sources)
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
CACNA1C, which encodes the L-type calcium channel Cav1.2 α subunit, was first shown to be genome-wide significant for bipolar disorder
confidence: 0.95
Robust support for one of these loci, the L-type calcium channel CACN1AC, has been obtained ... in a recent meta-analysis ...
confidence: 0.95
three genes with strong support had prior genome-wide significant associations with bipolar disorder: CACNA1C ...
confidence: 0.95
enhancement of signals at CACNA1C ... when schizophrenia and bipolar disorder were jointly analyzed
confidence: 0.95
Joint analysis with bipolar disorder (three genes, CACNA1C, ANK3 and ITIH3-ITIH4) described below.
confidence: 0.90
Genome-wide association study of bipolar disorder in European American and African American individuals.
(2009)
PMID:19488044
cited
highlighted three regions of interest: ... CACNA1C ...
confidence: 0.91
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
(2009)
PMID:19065143
cited
three genes ... CACNA1C ... meet criteria for genome-wide significance in bipolar disorder; meta-analysis p value of 7×10⁻⁸
confidence: 0.98