OPRM1 A118G associated_with OPRM1
Evidence from:
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all sources
Evidence (19 sources)
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
(2022)
PMID:36207451
primary
Separate analyses conditioning on rs1799971 ... to assess the interdependence of OPRM1 signals.
confidence: 0.90
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
(2022)
PMID:36207451
primary
The variant identified is the long‑studied rs1799971 (OPRM1‑A118G), a functional coding variant ... in the mu opioid receptor gene (OPRM1).
confidence: 0.96
Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol.
(2020)
PMID:32561311
primary
major functional OPRM1 SNP
confidence: 0.80
Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity.
(2017)
PMID:28134463
cited
Asp40 carriers of the OPRM1 gene ...
confidence: 0.95
Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity.
(2017)
PMID:28134463
cited
The most frequently studied polymorphism is the Asn40Asp SNP of the OPRM1 gene.
confidence: 0.95
Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G.
(2014)
PMID:22862850
cited
The A118G single nucleotide polymorphism (SNP) of the human µ opioid receptor gene (OPRM1)...
confidence: 0.96
The small number of pharmacogenetic studies analyzing the role of OPRM1 in nicotine dependence treatment have focused on the A118G polymorphism.
confidence: 0.95
Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G.
(2014)
PMID:22862850
cited
first exon of the human MOPR gene with A118 and G118
confidence: 0.90
Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.
(2013)
PMID:23136901
cited
The A118G SNP in the OPRM1 gene was assayed using a commercially available instrument and TaqMan assays.
confidence: 0.95
The most studied OPRM1 variant is the non-synonymous variant rs1799971 (118A>G, Asn40Asp).
confidence: 0.98
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.
(2012)
PMID:22954510
cited
A118G SNP of the OPRM1 gene
confidence: 0.96
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.
(2012)
PMID:22954510
cited
participants were prospectively genotyped at the A118G variant of OPRM1.
confidence: 0.95
As the 118A>G SNP changes an amino acid, it has been generally assumed that it is the causative variant for the phenotypes associated with it.
confidence: 0.96
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.
(2012)
PMID:22954510
cited
in addition to the A118G SNP of the OPRM1
confidence: 0.95
Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.
(2012)
PMID:22954510
cited
prospective genotyping based on the A118G SNP of the OPRM1 gene
confidence: 0.94
a common functional missense variant of the μ-opioid receptor (OPRM1 Asn40Asp)
confidence: 0.96
A genetic determinant of the striatal dopamine response to alcohol in men.
(2011)
PMID:20479755
cited
individuals carrying one or two copies of the variant 118G allele (118AG or 118GG genotype ...) of the OPRM1 polymorphism
confidence: 0.96
Haplotype block structure of the genomic region of the mu opioid receptor gene.
(2011)
PMID:21160491
cited
The non-synonymous variant rs1799971 (118A>G, Asn40Asp) ...
confidence: 0.96
Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis.
(2009)
PMID:23226031
cited
The most frequently studied OPRM1 variant is the single nucleotide polymorphism (SNP) A118G ... in exon 1
confidence: 0.95