GABRA2 associated_with alcohol dependence
Evidence from:
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Evidence (18 sources)
Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.
(2021)
PMID:34291596
primary
may be linked to ... hippocampal GABA ... in alcohol dependence
confidence: 0.80
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
(2021)
PMID:34446935
primary
extensively studied in relation to alcohol dependence35,36
confidence: 0.93
Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
(2018)
PMID:29947131
primary
consistent with its relation to ... alcohol dependence
confidence: 0.90
Candidate gene-environment interaction research: reflections and recommendations.
(2015)
PMID:25620996
primary
a recent meta-analysis confirms the evidence for association ... between GABRA2 and alcohol dependence
confidence: 0.92
Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence.
(2014)
PMID:23362995
primary
GABRA2 is associated with AD only in individuals with comorbid drug dependence
confidence: 0.90
Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence.
(2014)
PMID:23362995
primary
GABRA2 is associated with AD only in individuals with comorbid drug dependence
confidence: 0.90
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.
(2011)
PMID:21184583
primary
genetic determinants for ... alcohol dependence have been discovered ... GABRA2
confidence: 0.90
Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism.
(2006)
PMID:17373405
primary
The investigators identified several SNPs located in the GABRA2 gene that were associated with alcohol dependence.
confidence: 0.95
same GABAA receptor gene ... is associated with a diagnosis of alcohol dependence
confidence: 0.95
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
(2015)
PMID:26250693
cited
SNPs ... spanning the 3’-region of GABRA2 ... have been associated with alcohol dependence (AD).
confidence: 0.95
SNPs and their haplotypes throughout the gene encoding the GABAA α2 subunit (GABRA2) were associated with AD.
confidence: 0.95
selection of SNPs spanning the GABRA2 region including several SNPs that have been consistently associated with AD
confidence: 0.96
GABRA2 variants shown to be associated with AD
confidence: 0.90
several SNPs that have been consistently associated with AD
confidence: 0.95
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks.
(2012)
PMID:22348705
cited
Several candidate genes ... have been associated with alcohol dependence, including the genes encoding GABA A receptor, alpha 2 (GABRA2).
confidence: 0.95
The genetics of alcohol dependence: advancing towards systems-based approaches.
(2012)
PMID:22854292
cited
GABRA2 ... emerged in recent GWAS and is a well‑replicated candidate gene linked to alcohol use/alcoholism/AD
confidence: 0.90
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
(2012)
PMID:22488850
cited
GABRA2 ... have previously been associated to both alcohol and nicotine dependence
confidence: 0.95
An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back.
(2011)
PMID:34385894
cited
two genes that we have focused on ... are GABRA2 and CHRM2 ... involved in alcohol dependence
confidence: 0.96