EXT polygenic score associated_with substance use
Evidence from:
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Evidence (4 sources)
Trajectories of genetic risk across dimensions of alcohol use behaviors.
(2025)
PMID:40196263
primary
PGS was derived to index EXT, based on a GWAS meta-analysis of impulsivity-related traits and substance use
confidence: 0.96
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
(2021)
PMID:34446935
primary
The most abundant associations were with mental and behavioral disorders, such as substance use...
confidence: 0.95
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
(2021)
PMID:34446935
primary
polygenic scores for EXT ... selected for their detailed phenotypes related to ... substance use
confidence: 0.96
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
(2021)
PMID:34446935
primary
Polygenic scores for EXT explained significant variance ... in the categories ... substance use disorders (mean ΔR2 = 0.8–1.7%)
confidence: 0.95