chronic opioid use associated_with physical dependence
Evidence from:
primary |
all sources
Evidence (1 sources)
From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics.
(2009)
PMID:19214139
cited
the physical dependence, tolerance and hyperalgesia that can develop may limit the value of chronic narcotic therapy
confidence: 0.90