de novo variant risk_factor_for OCD
Evidence from:
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Evidence (6 sources)
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
(2020)
PMID:31771860
cited
identify de novo SNVs and insertion-deletion variants (indels) contributing to OCD
confidence: 0.94
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
(2020)
PMID:31771860
cited
genes identified by de novo damaging variants in OCD are functionally connected ... indicating these variants contribute to OCD risk
confidence: 0.90
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
(2020)
PMID:31771860
cited
Based on OCD proband vulnerability to de novo damaging variants in our dataset...
confidence: 0.90
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
(2020)
PMID:31771860
cited
We found a statistically significant increased rate of de novo LGD variants in OCD cases, confirming our hypothesis (RR 1.93, p=0.01).
confidence: 0.98
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
(2020)
PMID:31771860
cited
34% of de novo damaging mutations seen in OCD carry risk
confidence: 0.95
De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.
(2020)
PMID:31771860
cited
estimate the number of genes contributing risk to OCD, based on vulnerability to de novo damaging variants
confidence: 0.95