OPRM1 A118G risk_factor_for opioid dependence

haplotype consisting of the major rs1799971-A allele and minor alleles at all GWS OPRM1 variants ... was associated with increased risk

the equivocal findings at the individual rs1799971 variant level... may explain the relationship between haplotype structure and risk for OA

people with the minor allele might be at risk of opioid addiction

Several studies reported positive association of the 118G variant with opioid dependence

The Indian study yielded the largest OR of A118G between opioid-dependent and control groups with regard to both allele and genotype frequency.