Liu, Yunlong

Yunlong Liu’s research centers on the genetics and molecular neurobiology of alcohol‑use disorder, combining large‑scale human genomics with cellular and animal models to uncover how genetic risk translates into brain‑cell dysfunction and disease‑relevant phenotypes. He has pioneered integrated single‑nucleus RNA‑seq/ATAC‑seq profiling of the human caudate, demonstrated that polygenic risk scores predict AUD risk and remission as robustly as family history, linked AUD‑PRS to ethanol‑induced microglial activation, identified functional non‑coding variants through high‑throughput PASSPORT‑seq and allele‑specific expression assays, and used Mendelian‑randomization splicing and multi‑omics integration to pinpoint immune‑related pathways and novel risk genes that overlap with neurodegenerative disorders.