Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation.
paper
Cited
Public
- Authors
- Liu, Yunlong; Balaraman, Yokesh; Wang, Guohua; Nephew, Kenneth P; Zhou, Feng C
- Year
- 2009
- Journal
- Epigenetics
- PMID
- 20009564
- DOI
- 10.4161/epi.4.7.9925
- PMCID
- PMC2805036
Alcohol exposure during development can cause variable neurofacial deficit and growth retardation known as fetal alcohol spectrum disorders (FASD). The mechanism underlying FASD is not fully understood. However, alcohol, which is known to affect methyl donor metabolism, may induce aberrant epigenetic changes contributing to FASD. Using a tightly controlled whole-embryo culture, we investigated the effect of alcohol exposure (88mM) at early embryonic neurulation on genome-wide DNA methylation and gene expression in the C57BL/6 mouse. The DNA methylation landscape around promoter CpG islands at early mouse development was analyzed using MeDIP (methylated DNA immunoprecipitation) coupled with microarray (MeDIP-chip). At early neurulation, genes associated with high CpG promoters (HCP) had a lower ratio of methylation but a greater ratio of expression. Alcohol-induced alterations in DNA methylation were observed, particularly in genes on chromosomes 7, 10, and X; remarkably, a >10 fold increase in the number of genes with increased methylation on chromosomes 10 and X was observed in alcohol-exposed embryos with a neural tube defect phenotype compared to embryos without a neural tube defect. Significant changes in methylation were seen in imprinted genes, genes known to play roles in cell cycle, growth, apoptosis, cancer, and in a large number of genes associated with olfaction. Altered methylation was associated with significant (p<0.01) changes in expression for 84 genes. Sequenom EpiTYPER DNA methylation analysis was used for validation of the MeDIP-chip data. Increased methylation of genes known to play a role in metabolism (Cyp4f13) and decreased methylation of genes associated with development (Nlgn3, Elavl2, Sox21 and Sim1), imprinting (Igf2r) and chromatin (Hist1h3d) was confirmed. In a mouse model for FASD, we show for the first time that alcohol exposure during early neurulation can induce aberrant changes in DNA methylation patterns with associated changes in gene expression, which together may contribute to the observed abnormal fetal development.
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|---|---|---|---|---|
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| The role of DNA methylation in alcohol-mediated neurodevelopmental toxicity. | Gao J et al. | β | 2026 | β |
| Effects of alcohol on the transcriptome, methylome and metabolome of in vitro gastrulating human embryonic cells. | WallΓ©n E et al. | β | 2025 | β |
| Mechanisms of Alcohol Interference with Hippocampal Neurogenesis and its Repair Strategies. | Wang J et al. | β | 2025 | β |
| Longitudinal intravital imaging of mouse placenta. | Zhu X et al. | β | 2024 | β |
| Maternal diet supplemented with African walnuts enhances cortico-hippocampal gene expression and histomorphology in rat offspring. | Arogundade TT et al. | β | 2024 | β |
| Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment. | Karatayev O et al. | β | 2024 | β |
| The influence of epigenetics and inflammation on cardiometabolic risks. | Raghubeer S | β | 2024 | β |
| Altered Epigenetic Marks and Gene Expression in Fetal Brain, and Postnatal Behavioural Disorders, Following Prenatal Exposure of <i>Ogg1</i> Knockout Mice to Saline or Ethanol. | Bhatia S et al. | β | 2023 | β |
| Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH. | Darbinian N et al. | β | 2023 | β |
| DNA Methylation in Alcohol Use Disorder. | Zheng Q et al. | β | 2023 | β |
| Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances. | Mallick R et al. | β | 2023 | β |
| Epigenetics in fetal alcohol spectrum disorder. | Basavarajappa BS | β | 2023 | β |
| Epigenetics of Trauma Transmission and Fetal Alcohol Spectrum Disorder: What Does the Evidence Support? | Orton SM et al. | β | 2023 | β |
| miRNA Expression Analysis of the Hippocampus in a Vervet Monkey Model of Fetal Alcohol Spectrum Disorder Reveals a Potential Role in Global mRNA Downregulation. | Gillis RF et al. | β | 2023 | β |
| Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture. | Metruccio F et al. | β | 2023 | β |
| Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming. | Liu L et al. | β | 2023 | β |
| An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective. | Dvoran M et al. | β | 2022 | β |
| Autism Spectrum Disorder and Fetal Alcohol Spectrum Disorder: A Literature Review. | Carpita B et al. | β | 2022 | β |
| Effects of Genetics and Sex on Acute Gene Expression Changes in the Hippocampus Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mouse Strains. | Baker JA et al. | β | 2022 | β |
| Fetal Alcohol Spectrum Disorders: Awareness to Insight in Just 50 Years. | Charness ME | β | 2022 | β |
| mRNA expression analysis of the hippocampus in a vervet monkey model of fetal alcohol spectrum disorder. | Gillis RF et al. | β | 2022 | β |
| Use of Psychoactive Substances during the Perinatal Period: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives. | Chanal C et al. | β | 2022 | β |
| Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1. | Liu Y et al. | β | 2021 | β |
| Epigenetic Impacts of Early Life Stress in Fetal Alcohol Spectrum Disorders Shape the Neurodevelopmental Continuum. | Alberry B et al. | β | 2021 | β |
| Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain. | Toth M | β | 2021 | β |
| Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure. | Jawaid S et al. | β | 2021 | β |
| Intersection of Epigenetic and Immune Alterations: Implications for Fetal Alcohol Spectrum Disorder and Mental Health. | Lussier AA et al. | β | 2021 | β |
| Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms. | Polverino A et al. | β | 2021 | β |
| The Effects of Early Prenatal Alcohol Exposure on Epigenome and Embryonic Development. | WallΓ©n E et al. | β | 2021 | β |
| Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications. | CiafrΓ¨ S et al. | β | 2020 | β |
| Association between maternal periconceptional alcohol consumption and neural tube defects: Findings from the National Birth Defects Prevention Study, 1997-2011. | Louden AR et al. | β | 2020 | β |
| Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms. | Kaminen-Ahola N | β | 2020 | β |
| Prenatal alcohol exposure and developmental programming of mental illness. | Burgess DJ et al. | β | 2020 | β |
| DNA methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes. | Cobben JM et al. | β | 2019 | β |
| Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation. | Cantacorps L et al. | β | 2019 | β |
| p53-Mediated Activities in NS-5 Neural Stem Cells: Effects of Ethanol. | Miller MW | β | 2019 | β |
| Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders. | Ehrhart F et al. | β | 2019 | β |
| Alcohol-Related Alterations in Placental Imprinted Gene Expression in Humans Mediate Effects of Prenatal Alcohol Exposure on Postnatal Growth. | Carter RC et al. | β | 2018 | β |
| Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology. | Georgieff MK et al. | β | 2018 | β |
| CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice. | Subbanna S et al. | β | 2018 | β |
| DNA methylation as a predictor of fetal alcohol spectrum disorder. | Lussier AA et al. | β | 2018 | β |
| Early prenatal alcohol exposure alters imprinted gene expression in placenta and embryo in a mouse model. | Marjonen H et al. | β | 2018 | β |
| Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning. | Boschen KE et al. | β | 2018 | β |
| The impact of epigenomic next-generation sequencing approaches on our understanding of neuropsychiatric disorders. | Schang AL et al. | β | 2018 | β |
| Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology. | Chastain LG et al. | β | 2017 | β |
| Changes to histone modifications following prenatal alcohol exposure: An emerging picture. | Chater-Diehl EJ et al. | β | 2017 | β |
| Chromatin Switches during Neural Cell Differentiation and Their Dysregulation by Prenatal Alcohol Exposure. | Gavin DP et al. | β | 2017 | β |
| Developmental ethanol exposure impairs locomotor movement in Japanese medaka (Oryzias latipes) larvae targeting epigenome. | Dasmahapatra AK et al. | β | 2017 | β |
| Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure. | Veazey KJ et al. | β | 2017 | β |
| DNA Methylation program in normal and alcohol-induced thinning cortex. | ΓztΓΌrk NC et al. | β | 2017 | β |
| Do toxic metals and trace elements have a role in the pathogenesis of conotruncal heart malformations? | Kundak AA et al. | β | 2017 | β |
| Epigenetics: a link between addiction and social environment. | Ajonijebu DC et al. | β | 2017 | β |
| Epigenetics studies of fetal alcohol spectrum disorder: where are we now? | Lussier AA et al. | β | 2017 | β |
| Epigenetic studies in Developmental Origins of Health and Disease: pitfalls and key considerations for study design and interpretation. | Yamada L et al. | β | 2017 | β |
| Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus. | Mandal C et al. | β | 2017 | β |
| Impact of exercise and a complex environment on hippocampal dendritic morphology, Bdnf gene expression, and DNA methylation in male rat pups neonatally exposed to alcohol. | Boschen KE et al. | β | 2017 | β |
| Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders. | Laufer BI et al. | β | 2017 | β |
| Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring. | Banik A et al. | β | 2017 | β |
| rs10732516 polymorphism at the <i>IGF2/H19</i> locus associates with a genotype-specific trend in placental DNA methylation and head circumference of prenatally alcohol-exposed newborns. | Marjonen H et al. | β | 2017 | β |
| Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3. | Qi C et al. | β | 2017 | β |
| Supplementation with the Methyl Donor Betaine Prevents Congenital Defects Induced by Prenatal Alcohol Exposure. | Karunamuni G et al. | β | 2017 | β |
| The BAF (BRG1/BRM-Associated Factor) chromatin-remodeling complex exhibits ethanol sensitivity in fetal neural progenitor cells and regulates transcription at the miR-9-2 encoding gene locus. | Burrowes SG et al. | β | 2017 | β |
| Activity-dependent synaptic plasticity modulates the critical phase of brain development. | Chaudhury S et al. | β | 2016 | β |
| Alcohol-induced suppression of KDM6B dysregulates the mineralization potential in dental pulp stem cells. | Hoang M et al. | β | 2016 | β |
| Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. | Chater-Diehl EJ et al. | β | 2016 | β |
| Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. | Oni EN et al. | β | 2016 | β |
| Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies. | Shapiro AM et al. | β | 2016 | β |
| Consumption of Substances of Abuse during Pregnancy Increases Consumption in Offspring: Possible Underlying Mechanisms. | Poon K et al. | β | 2016 | β |
| DNA methylation signature of human fetal alcohol spectrum disorder. | Portales-Casamar E et al. | β | 2016 | β |
| Epigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral Deficits. | Basavarajappa BS et al. | β | 2016 | β |
| Male germline transmits fetal alcohol epigenetic marks for multiple generations: a review. | Sarkar DK | β | 2016 | β |
| Meta-Analysis of Gene Expression Patterns in Animal Models of Prenatal Alcohol Exposure Suggests Role for Protein Synthesis Inhibition and Chromatin Remodeling. | Rogic S et al. | β | 2016 | β |
| Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis. | Rojas-MayorquΓn AE et al. | β | 2016 | β |
| Associative DNA methylation changes in children with prenatal alcohol exposure. | Laufer BI et al. | β | 2015 | β |
| Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling. | JimΓ©nez-ChillarΓ³n JC et al. | β | 2015 | β |
| CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation. | Nagre NN et al. | β | 2015 | β |
| DNA methyltransferase expressions in Japanese rice fish (Oryzias latipes) embryogenesis is developmentally regulated and modulated by ethanol and 5-azacytidine. | Dasmahapatra AK et al. | β | 2015 | β |
| Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. | Veazey KJ et al. | β | 2015 | β |
| Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model. | Marjonen H et al. | β | 2015 | β |
| Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention. | Romani M et al. | β | 2015 | β |
| Epigenetic mechanisms: A possible link between autism spectrum disorders and fetal alcohol spectrum disorders. | Varadinova M et al. | β | 2015 | β |
| Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation. | Blaze J et al. | β | 2015 | β |
| Fetal alcohol exposure and mammary tumorigenesis in offspring: role of the estrogen and insulin-like growth factor systems. | Cohick WS et al. | β | 2015 | β |
| Gene-specific disruption of endocannabinoid receptor 1 (cnr1a) by ethanol probably leads to the development of fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish (Oryzias latipes) embryogenesis. | Dasmahapatra AK et al. | β | 2015 | β |
| Lifestyle, pregnancy and epigenetic effects. | Barua S et al. | β | 2015 | β |
| Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain. | Ngai YF et al. | β | 2015 | β |
| Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study. | Masemola ML et al. | β | 2015 | β |
| The effects of early life stress on the epigenome: From the womb to adulthood and even before. | ProvenΓ§al N et al. | β | 2015 | β |
| Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells. | ProvenΓ§al N et al. | β | 2014 | β |
| DNA modifications: function and applications in normal and disease States. | Liyanage VR et al. | β | 2014 | β |
| Early life epigenetic programming and transmission of stress-induced traits in mammals: how and when can environmental factors influence traits and their transgenerational inheritance? | Gapp K et al. | β | 2014 | β |
| Early life ethanol exposure causes long-lasting disturbances in rat mesenchymal stem cells via epigenetic modifications. | Leu YW et al. | β | 2014 | β |
| Environmental alterations of epigenetics prior to the birth. | Lo CL et al. | β | 2014 | β |
| Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. | Gangisetty O et al. | β | 2014 | β |
| Fetal alcohol spectrum disorder: pathogenesis and mechanisms. | Sulik KK | β | 2014 | β |
| Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms. | Mead EA et al. | β | 2014 | β |
| Impaired one carbon metabolism and DNA methylation in alcohol toxicity. | Kruman II et al. | β | 2014 | β |
| Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response. | Harper KM et al. | β | 2014 | β |
| Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders. | Kleiber ML et al. | β | 2014 | β |
| Methylome repatterning in a mouse model of Maternal PKU Syndrome. | Dobrowolski SF et al. | β | 2014 | β |
| Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: from immediate effects to long-term adaptation. | Mantha K et al. | β | 2014 | β |
| Molecular pathways underpinning ethanol-induced neurodegeneration. | Goldowitz D et al. | β | 2014 | β |
| MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD. | Nieratschker V et al. | β | 2014 | β |
| Paternal ethanol exposure and behavioral abnormities in offspring: associated alterations in imprinted gene methylation. | Liang F et al. | β | 2014 | β |
| Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes. | Zhang X et al. | β | 2014 | β |
| Study protocol: Asking QUestions about Alcohol in pregnancy (AQUA): a longitudinal cohort study of fetal effects of low to moderate alcohol exposure. | Muggli E et al. | β | 2014 | β |
| The epigenetic landscape of alcoholism. | Krishnan HR et al. | β | 2014 | β |
| The epigenome and cancer prevention: A complex story of dietary supplementation. | Lee HS et al. | β | 2014 | β |
| Alcohol exposure during development: Impact on the epigenome. | Perkins A et al. | β | 2013 | β |
| Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation. | Veazey KJ et al. | β | 2013 | β |
| Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts. | Mukhopadhyay P et al. | β | 2013 | β |
| Association of maternal and nutrient supply line factors with DNA methylation at the imprinted IGF2/H19 locus in multiple tissues of newborn twins. | Loke YJ et al. | β | 2013 | β |
| Commonality in Down and fetal alcohol syndromes. | Solzak JP et al. | β | 2013 | β |
| Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid. | Sarmah S et al. | β | 2013 | β |
| DNA methylation program in developing hippocampus and its alteration by alcohol. | Chen Y et al. | β | 2013 | β |
| Epigenetic consequences of a changing human diet. | Haggarty P | β | 2013 | β |
| Epigenetic dynamics in psychiatric disorders: environmental programming of neurodevelopmental processes. | Kofink D et al. | β | 2013 | β |
| Epigenetic medicine and fetal alcohol spectrum disorders. | Resendiz M et al. | β | 2013 | β |
| Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex Mechanisms and Potential Therapeutic Targets. | Muralidharan P et al. | β | 2013 | β |
| Folate, homocysteine and the cardiac neural crest. | Rosenquist TH | β | 2013 | β |
| Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in Ξ²-endorphin-producing POMC neurons of the hypothalamus. | Bekdash RA et al. | β | 2013 | β |
| In utero alcohol exposure, epigenetic changes, and their consequences. | Ungerer M et al. | β | 2013 | β |
| Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. | Laufer BI et al. | β | 2013 | β |
| Long-term health consequences of early-life exposure to substance abuse: an epigenetic perspective. | Vaiserman AM | β | 2013 | β |
| Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. | Kleiber ML et al. | β | 2013 | β |
| Neurodevelopmental epigenetic etiologies: insights from studies on mouse models of fetal alcohol spectrum disorders. | Laufer BI et al. | β | 2013 | β |
| Prenatal alcohol exposure and cellular differentiation: a role for Polycomb and Trithorax group proteins in FAS phenotypes? | Veazey KJ et al. | β | 2013 | β |
| Prenatal ethanol exposure disrupts intraneocortical circuitry, cortical gene expression, and behavior in a mouse model of FASD. | El Shawa H et al. | β | 2013 | β |
| Systems pharmacology to predict drug toxicity: integration across levels of biological organization. | Bai JP et al. | β | 2013 | β |
| The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects. | Linask KK | β | 2013 | β |
| Time course of SERCA 2b and calreticulin expression in Purkinje neurons of ethanol-fed rats with behavioral correlates. | Cassidy LL et al. | β | 2013 | β |
| Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. | Herceg Z et al. | β | 2013 | β |
| Choline supplementation and DNA methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development. | Otero NK et al. | β | 2012 | β |
| DNA methylation program during development. | Zhou FC | β | 2012 | β |
| Early origins of adult disease: approaches for investigating the programmable epigenome in humans, nonhuman primates, and rodents. | Ganu RS et al. | β | 2012 | β |
| Effects of heavy prenatal alcohol exposure and iron deficiency anemia on child growth and body composition through age 9 years. | Carter RC et al. | β | 2012 | β |
| Environmental toxicants--induced epigenetic alterations and their reversers. | Kim M et al. | β | 2012 | β |
| Epigenetic changes in lymphocytes of solvent-exposed individuals. | Godderis L et al. | β | 2012 | β |
| Epigenetics-beyond the genome in alcoholism. | Starkman BG et al. | β | 2012 | β |
| Ethanol exposure alters protein expression in a mouse model of fetal alcohol spectrum disorders. | Mason S et al. | β | 2012 | β |
| Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure. | Downing C et al. | β | 2012 | β |
| Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders. | Kleiber ML et al. | β | 2012 | β |
| Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression. | Donohoe DR et al. | β | 2012 | β |
| Nutrition and the epigenome. | Haggarty P | β | 2012 | β |
| The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring. | Knezovich JG et al. | β | 2012 | β |
| The epigenetic lorax: gene-environment interactions in human health. | Latham KE et al. | β | 2012 | β |
| The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. | ProvenΓ§al N et al. | β | 2012 | β |
| A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. | McClure KD et al. | β | 2011 | β |
| Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation. | Zhou FC et al. | β | 2011 | β |
| Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellum. | Guo W et al. | β | 2011 | β |
| Alteration of gene expression by alcohol exposure at early neurulation. | Zhou FC et al. | β | 2011 | β |
| Cellular DNA methylation program during neurulation and its alteration by alcohol exposure. | Zhou FC et al. | β | 2011 | β |
| Cortical thickness in fetal alcohol syndrome and attention deficit disorder. | FernΓ‘ndez-JaΓ©n A et al. | β | 2011 | β |
| Epigenetics and lifestyle. | AlegrΓa-Torres JA et al. | β | 2011 | β |
| Focus on: epigenetics and fetal alcohol spectrum disorders. | Kobor MS et al. | β | 2011 | β |
| Maternal voluntary drinking in C57BL/6J mice: advancing a model for fetal alcohol spectrum disorders. | Kleiber ML et al. | β | 2011 | β |
| Methylation analysis of circadian clock gene promoters in forensic autopsy specimens. | Nakatome M et al. | β | 2011 | β |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | β | 2011 | β |
| Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus. | Zink M et al. | β | 2011 | β |
| Prenatal exposure to ethanol: a specific effect on the H19 gene in sperm. | Stouder C et al. | β | 2011 | β |
| Using genomics for birth defects epidemiology: can epigenetics cut the GxE Gordian knot? | Friedman JM | β | 2011 | β |
| Advances in genome-wide DNA methylation analysis. | Gupta R et al. | β | 2010 | β |
| Epigenetic modifications in valproic acid-induced teratogenesis. | Tung EW et al. | β | 2010 | β |
| Epigenomic disruption: the effects of early developmental exposures. | Bernal AJ et al. | β | 2010 | β |
| Ethanol-induced methylation of cell cycle genes in neural stem cells. | Hicks SD et al. | β | 2010 | β |
| Folate protection from congenital heart defects linked with canonical Wnt signaling and epigenetics. | Linask KK et al. | β | 2010 | β |
| Genetic and epigenetic insights into fetal alcohol spectrum disorders. | Ramsay M | β | 2010 | β |
| How genome-wide approaches can be used to unravel the remaining secrets of the imprintome. | Cooper WN et al. | β | 2010 | β |
| Role of central nervous system insulin resistance in fetal alcohol spectrum disorders. | de la Monte SM et al. | β | 2010 | β |
| Role of environmental factors in axial skeletal dysmorphogenesis. | Alexander PG et al. | β | 2010 | β |
| Role of epigenetics in Alzheimer's and Parkinson's disease. | Kwok JB | β | 2010 | β |