Epigenetic modifications, primarily DNA methylation and histone modification, regulate key developmental events, including germ cell imprinting,1 stem cell maintenance,2–7 cell fate and tissue patterning.8 Epigenetics not only affects the expression of individual genes but also plays crucial roles in shaping developmental patterns, contributing to tissue-specific changes and maintenance of cellular memory required for developmental stability.8,9 Moreover, aberrant epigenetic changes in response to environmental stimuli have been shown to contribute to developmental disorders.10
