Chunk #50 — FINDINGS — Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death — Apolipoprotein E Allele Status (APOE) and Other Genetic Variants
The APOE ε4 allele was associated with a greater rate of decline in motor function [83]. CR1 and PICALM were also associated with cognitive decline and AD risk [84]. CR1 was also associated with amyloid angiopathy [140]. The 1405V CEPT polymorphism was was also associated with risk of AD and cognitive decline [141]. Genome-wide data are available and have been used in a number of collaborative projects [85,142–148].
