Information on samples and phenotypes is provided in the Supplementary Information Section 1. Briefly, neuroticism data were available for 17 875 (58% female) individuals (mean age 39.07; s.d.=16.02, range: 14–86). After estimation of the pairwise genetic similarity using all autosomal markers and deleting one of each pair of individuals with a genetic relatedness >0.025 (See Supplementary Information Section 1), 11 961 (58% females) individuals were retained (mean age 42.36; s.d.=16.91, range: 14–86). For extraversion, data from 17 557 individuals (59% female) individuals were available (mean age 39.01; s.d.=16.18, range: 14–86) of whom 11 786 (58% females) were genetically ‘unrelated' (mean age 42.36; s.d.=17.09, range: 14–86).
