The method applied in the present study is extensively described by Yang et al.43, 45 and is designed to capture variation due to LD between genotyped SNPs and unknown causal variants in the genome. This estimate of variance explained by all SNPs is different from heritability estimates in twin and family studies as the latter include variance explained by all causal variants (an estimate of the latent genetic effect). For more detailed information on the methods see Supplementary Information Section 2.
